Research
Find research shared by the Owlstown community.
The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
Abstract
SUMMARY Despite correlations between histone methyltransferase (HMT) activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histo...
Publication · August 25, 2026
Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory
Abstract
Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain l...
Publication · August 25, 2026
Endogenous MLL1 is dispensable for MLL-rearranged leukemia, but promotes acute leukemia driven by other oncoproteins
Publication · August 25, 2026
NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis
Abstract
Summary The Nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here we demonstrate that NUP98 fusion proteins, including NUP98-HOXA9 (NHA9), NUP98-HOXD13 (NHD13), NUP98-NSD1, NUP98...
Publication · August 25, 2026
Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets
Abstract
ABSTRACT The reported incidence of pancreatic neuroendocrine tumors (PanNETs) has increased, due in large part to improvements in detection and awareness. However, therapeutic options are limited and a critical need exists for understan...
Publication · August 25, 2026
Owlstown helps you launch your academic website in minutes.
Easy to update, no code, no server maintenance.
So you can focus on what matters: your research.
Get started free