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MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Publication · August 25, 2026
MLL2, not MLL1, Plays a Major Role in Sustaining MLL-rearranged Acute Myeloid Leukemia
Abstract
Summary The MLL1 histone methyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leukemia. The remaining wild-type allele is most commonly, but not always, retained. To what extent the wild-type...
Publication · August 25, 2026
Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia
Abstract
Disrupting protein-protein interaction for molecularly targeted cancer therapeutics can be a challenging but promising strategy. Compounds that disrupt the interaction between Menin, a chromatin-binding protein, and oncogenic MLL fusion...
Publication · August 25, 2026
MLL1 promotes IL-7 responsiveness and survival during B-cell differentiation
Abstract
B lymphocyte differentiation is an exquisitely regulated homeostatic process resulting in continuous production of appropriately selected B cells. Relatively small changes in gene expression can result in deregulation of this process, l...
Publication · August 25, 2026
Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation
Abstract
ABSTRACT The deregulation of hematopoietic stem cell (HSC) transcriptional networks is a common theme in acute myelogenous leukemia (AML). Chromosomal translocations that alter the Mixed Lineage Leukemia 1 gene (MLL1, MLL, KMT2A) occur ...
Publication · August 25, 2026
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
Abstract
PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. We previously found that PAX7 recruits th...
Publication · August 25, 2026
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
Abstract
In this study, Hurtz et al. used genetic mouse models and patient-derived leukemia cells to show that the transcriptional repressor BCL6 functions as a central driver of drug resistance in MLL-rearranged B-cell leukemia. Their genetic a...
Publication · August 25, 2026
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
Abstract
ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug target, developing ASH1L inhibitors is challenging, as the catalytic SET...
Publication · August 25, 2026
Menin is necessary for long term maintenance of meningioma-1 driven leukemia
Abstract
Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length protein, or as a fusion protein that includes most of the N-terminus of MN1. High leve...
Publication · August 25, 2026
Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
Abstract
Summary Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its m...
Publication · August 25, 2026
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