Research
Find research shared by the Owlstown community.
Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells
Abstract
RUNX1 encodes a DNA binding subunit of the core-binding transcription factors and is frequently mutated in acute leukemia, therapy-related leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia. Mutations in RUNX1 are t...
Publication · August 25, 2026
The diaphragms of fenestrated endothelia – gatekeepers of vascular permeability and blood composition
Abstract
SUMMARY Fenestral and stomatal diaphragms are endothelial subcellular structures of unknown function that form on organelles implicated in vascular permeability: fenestrae, transendothelial channels and caveolae. PV1 protein is required...
Publication · August 25, 2026
Cell context in the control of self-renewal and proliferation regulated by MLL1
Publication · August 25, 2026
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Publication · August 25, 2026
Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis
Abstract
Objective—To investigate the role of acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in hematopoiesis. Approach and Results—ACAT1 converts cellular cholesterol to cholesteryl esters for storage in multiple cell types and is a potential d...
Publication · August 25, 2026
Role of MLL-Wild Type in hematopoesis and leukemia transformation in MLL-Partial Tandem Duplication mouse models
Publication · August 25, 2026
Endogenous MLL1 is dispensable for the maintenance of MLL-rearranged leukemia
Publication · August 25, 2026
CONSERVED HIGHER ORDER CHROMATIN REGULATES NMDA RECEPTOR GENE EXPRESSION AND COGNITION
Abstract
3-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here, we describe activity-regulated long-range loopings bypassing up to 0.5 megabase o...
Publication · August 25, 2026
Owlstown helps you launch your academic website in minutes.
Easy to update, no code, no server maintenance.
So you can focus on what matters: your research.
Get started free