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An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Publication · August 25, 2026
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Publication · August 25, 2026
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
Abstract
HOX genes have emerged as critical effectors of leukemogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors CDX1, CDX2, and CD...
Publication · August 25, 2026
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.
Publication · August 25, 2026
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Abstract
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolutionarily conserved chromatin remodelling system that act...
Publication · August 25, 2026
Developmentally-induced Mll1 loss reveals defects in postnatal haematopoiesis
Abstract
The mixed lineage leukemia (MLL) gene is disrupted by chromosomal translocations in acute leukemia, producing a fusion oncogene with altered properties relative to the wild-type gene. Murine loss-of-function studies have shown an essent...
Publication · August 25, 2026
MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele
Abstract
SUMMARY Oncogenic fusion proteins are capable of initiating tumorigenesis but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, res...
Publication · August 25, 2026
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