Research
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NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment
Abstract
This study examined whether cerebrospinal fluid (CSF) baseline levels of the synaptic protein NPTX2 predict time to onset of symptoms of mild cognitive impairment (MCI), both alone and when accounting for traditional CSF Alzheimer's dis...
Publication · February 01, 2026
Active Needle Tracking with Wearable 2-DOF Ultrasound Scanner for Lumbar Puncture Guidance
Abstract
Lumbar punctures can be challenging for patients with obesity, pregnancy or spine-malformation, due to the inability to bend the back and open up the interspinous gap for needle access. Therefore, we are proposing a new wearable device-...
Publication · February 01, 2026
Four‐dimensional proteomics analysis of human cerebrospinal fluid with trapped ion mobility spectrometry using PASEF
Abstract
A quadrupole time‐of‐flight mass spectrometer coupled with a trapped ion mobility spectrometry (timsTOF) operated in parallel accumulation‐serial fragmentation (PASEF) mode has recently emerged as a platform capable of providing four‐di...
Publication · February 01, 2026
MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging
Abstract
White matter damage is a feature of Alzheimer's disease, yet little is known about how facets of the Alzheimer's disease process relate to key features of white matter structure. We examined the association of Alzheimer's disease (Aß42/...
Publication · February 01, 2026
Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma
Abstract
BACKGROUND: Proteins expressed by brain endothelial cells (BECs), the primary cell type of the blood-brain barrier, may serve as sensitive plasma biomarkers for neurological and neurovascular conditions, including cerebral small vessel ...
Publication · February 01, 2026
Plasma biomarkers in relation to spatial distribution of Alzheimer’s disease neuropathology
Abstract
The clinical utility of plasma biomarkers will in part be based on the information they convey regarding the distribution of neuropathology, especially beyond the information provided by demographics. We examined the associations of pla...
Publication · February 01, 2026
Regional White Matter Hyperintensities and Alzheimer’s Disease Biomarkers Among Older Adults with Normal Cognition and Mild Cognitive Impairment
Abstract
Background: Alzheimer’s disease (AD) frequently co-occurs with other brain pathologies. Recent studies suggest there may be a mechanistic link between AD and small vessel cerebrovascular disease (CVD), as opposed to simply the overlap o...
Publication · February 01, 2026
B - 92 Poor Olfaction Prior to Cardiac Surgery: Associations with Cognition, Plasma Neurofilament Light and Postoperative Delirium in a Prospective Nested Cohort Study.
Abstract
OBJECTIVE
This study examined the association between pre-operative olfactory performance and delirium after cardiac surgery. As a secondary aim, we examined the relationship between baseline olfaction, cognitive functioning, and plasma...
Publication · February 01, 2026
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