Research
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Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk
Abstract
Few studies have comprehensively examined how health and disease risk influence Alzheimer's disease (AD) biomarkers. The present study examined the association of 14 protein‐based health indicators with plasma and neuroimaging biomarker...
Publication · February 01, 2026
Skeletal muscle mitochondrial function predicts cognitive impairment and is associated with biomarkers of Alzheimer's disease and neurodegeneration
Abstract
Mitochondrial dysfunction is implicated in the pathophysiology of many chronic diseases. Whether it is related to cognitive impairment and pathological markers is unknown.
Publication · February 01, 2026
Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid
Abstract
Given the persistent challenge of differentiating idiopathic Normal Pressure Hydrocephalus (iNPH) from similar clinical entities, we conducted an in-depth proteomic study of cerebrospinal fluid (CSF) in 28 shunt-responsive iNPH patients...
Publication · February 01, 2026
VICTR: Venous transit time imaging by changes in T1 relaxation
Abstract
Abnormalities in cerebral veins are a common finding in many neurological diseases, yet there is a scarcity of MRI techniques to assess venous hemodynamic function. The present study aims to develop a noncontrast technique to measure a ...
Publication · February 01, 2026
Association of Plasma Markers of Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging
Abstract
The choroid plexus (CP) is a vital brain structure essential for cerebrospinal fluid (CSF) production. Moreover, alterations in the CP’s structure and function are implicated in molecular conditions and neuropathologies including multip...
Publication · February 01, 2026
Neuronal pentraxin 2 correlates with neurodegeneration but not cognition in idiopathic normal pressure hydrocephalus (iNPH).
Abstract
AIM OF THE STUDY
Neuronal pentraxin-2 (NPTX2) is a synaptic protein responsible for modulating plasticity at excitatory synapses. While the role of NPTX2 as a novel synaptic biomarker in cognitive disorders has been elucidated recently,...
Publication · February 01, 2026
Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline
Abstract
Infections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respirato...
Publication · February 01, 2026
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression
Publication · February 01, 2026
Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment
Abstract
Key Points Question What factors are associated with the acceleration of brain atrophy and progression to mild cognitive impairment (MCI) based on long-term longitudinal data for individuals with normal cognition at baseline? Findings I...
Publication · February 01, 2026
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