Research
Find research shared by the Owlstown community.
Herpes Viruses in the Baltimore Longitudinal Study of Aging
Abstract
Background and Objectives Although an infectious etiology of Alzheimer disease (AD) has received renewed attention with a particular focus on herpes viruses, the longitudinal effects of symptomatic herpes virus (sHHV) infection on brain...
Publication · February 01, 2026
Developing a “Fast-Track” Strategy for Interventional Management of Patients With Idiopathic Intracranial Hypertension
Abstract
Idiopathic intracranial hypertension (IIH) has an increasing incidence worldwide over the past decade, with a high economic burden on patients and society. Up to 10% of patients with IIH have progressive visual decline requiring an inva...
Publication · February 01, 2026
MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe
Publication · February 01, 2026
Proteomic indicators of health relate to Alzheimer’s and neurodegenerative disease biomarkers
Abstract
Prior studies suggest that peripheral health and comorbid disease can influence Alzheimer’s disease (AD) pathology and neurodegenerative processes. However, no studies to date have comprehensively examined how measures of peripheral hea...
Publication · February 01, 2026
CSF Alzheimer Disease Biomarkers
Abstract
Background and Objectives This study aimed to examine whether baseline CSF measures of Alzheimer disease (AD)–related pathology are associated with the time to onset of mild cognitive impairment (MCI) and whether these associations diff...
Publication · February 01, 2026
The Clinical Utility of the MOCA in iNPH Assessment
Abstract
Objectives We sought to estimate reliable change thresholds for the Montreal Cognitive Assessment (MoCA) for older adults with suspected Idiopathic Normal Pressure Hydrocephalus (iNPH). Furthermore, we aimed to determine the likelihood ...
Publication · February 01, 2026
Causal links among amyloid, tau, and neurodegeneration.
Abstract
Amyloid-β pathology is associated with greater tau pathology and facilitates tau propagation from the medial temporal lobe to the neocortex, where tau is closely associated with local neurodegeneration. The degree of the involvement of ...
Publication · February 01, 2026
Inpatient healthcare burden and variables influencing hydrocephalus-related admissions across the lifespan.
Abstract
OBJECTIVE
The aims of this study were to quantify inpatient healthcare costs, describe patient demographics, and analyze variables influencing costs for pediatric and adult hydrocephalus shunt-related admissions in the US.
METHODS
A cr...
Publication · February 01, 2026
Olfaction, Cognitive Impairment, and PET Biomarkers in Community-Dwelling Older Adults
Abstract
Background: Olfactory deficits are early features of preclinical Alzheimer’s disease (AD). Whether olfaction is associated with PET biomarkers among community-dwelling older adults is less clear. Objective: Investigate cross-sectional a...
Publication · February 01, 2026
Cerebrospinal Fluid Alzheimer’s Disease Biomarker Patterns of Change Prior to the Onset of Mild Cognitive Impairment
Abstract
Background: Cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are altered many years before the onset of clinical symptoms of mild cognitive impairment (MCI). Incorporating clinical symptom onset time into biomarker model...
Publication · February 01, 2026