Research
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Perioperative Neurofilament Light Plasma Concentrations and Cognition before and after Cardiac Surgery: A Prospective Nested Cohort Study
Abstract
Background: Neurofilament light is a marker of neuronal injury and can be measured in blood. Postoperative increases in neurofilament light have been associated with delirium after noncardiac surgery. However, few studies have examined ...
Publication · February 01, 2026
Blood–brain barrier permeability in response to caffeine challenge
Abstract
Caffeine is known to alter brain perfusion by acting as an adenosine antagonist, but its effect on blood–brain barrier (BBB) permeability is not fully elucidated. This study aimed to dynamically monitor BBB permeability to water after a...
Publication · February 01, 2026
CSF Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus
Abstract
Background and Objectives The assessment of biomarkers in selecting patients with idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery has been limited to small cohort studies and those with limited follow-up. We assessed t...
Publication · February 01, 2026
Placebo-Controlled Effectiveness of Idiopathic Normal Pressure Hydrocephalus Shunting: A Randomized Pilot Trial
Abstract
BACKGROUND: Multiple prospective nonrandomized studies have shown 60% to 70% of patients with idiopathic normal pressure hydrocephalus (iNPH) improve with shunt surgery, but multicenter placebo-controlled trial data are necessary to det...
Publication · February 01, 2026
Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA)
Abstract
Background: Gradual disengagement from daily physical activity (PA) could signal present or emerging mild cognitive impairment (MCI) or Alzheimer’s disease (AD). Objective: This study examined whether accelerometry-derived patterns of e...
Publication · February 01, 2026
Safety and effectiveness of the assessment and treatment of idiopathic normal pressure hydrocephalus in the Adult Hydrocephalus Clinical Research Network.
Abstract
OBJECTIVE
The aim of this study was to describe the processes and outcomes associated with patients at five sites in the Adult Hydrocephalus Clinical Research Network (AHCRN) who had undergone evaluation and treatment for suspected idio...
Publication · February 01, 2026
AutoInFocus, a new paradigm for ultrasound-guided spine intervention: a multi-platform validation study
Publication · February 01, 2026
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease
Abstract
Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associa...
Publication · February 01, 2026
Structural and Functional Brain Connectivity Uniquely Contribute to Episodic Memory Performance in Older Adults
Abstract
In this study, we examined the independent contributions of structural and functional connectivity markers to individual differences in episodic memory performance in 107 cognitively normal older adults from the BIOCARD study. Structura...
Publication · February 01, 2026
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