Research
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Systematic volumetric analysis predicts response to CSF drainage and outcome to shunt surgery in idiopathic normal pressure hydrocephalus
Abstract
Idiopathic normal pressure hydrocephalus (INPH) is a neurodegenerative disorder characterized by excess cerebrospinal fluid (CSF) in the ventricles, which can be diagnosed by invasive CSF drainage test and treated by shunt placement. He...
Publication · February 01, 2026
MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols
Abstract
The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple ...
Publication · February 01, 2026
Cognitive and gait outcomes after primary endoscopic third ventriculostomy in adults with chronic obstructive hydrocephalus.
Abstract
OBJECTIVE
The object of this study was to determine the short- and long-term efficacy of primary endoscopic third ventriculostomy (ETV) on cognition and gait in adults with chronic obstructive hydrocephalus.
METHODS
Patients were prosp...
Publication · February 01, 2026
Intracranial Hypotension Related Skull Remodeling with Enophthalmos
Abstract
Drs Pirakitikulr and Tse describe their experience managing a patient with progressive enophthalmos following cerebrospinal fluid (CSF) shunting. The case is interesting and nicely illustrates several valuable features of this uncommon ...
Publication · February 01, 2026
Longitudinal CSF biomarker trajectories from middle age to late adulthood
Abstract
Current cerebrospinal fluid (CSF) biomarker data of preclinical AD are based largely on cross‐sectional studies across the disease spectrum and short‐term longitudinal studies, with most studies conducted among older adults. However, ne...
Publication · February 01, 2026
Health Conditions Associated with Alzheimer's Disease and Vascular Dementia
Abstract
We examined medical records to determine health conditions associated with dementia at varied intervals prior to dementia diagnosis in participants from the Baltimore Longitudinal Study of Aging (BLSA).
Publication · February 01, 2026
Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology
Abstract
Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery and consumption. We longitudinally measured OEF in older adults to examine the relationship with markers of Alzheimer's disease (AD) and vascular pathology.
Publication · February 01, 2026
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
Abstract
Trigeminal neuralgia, historically dubbed the “suicide disease,” is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)–app...
Publication · February 01, 2026
Feature-aggregated spatiotemporal spine surface estimation for wearable patch ultrasound volumetric imaging
Abstract
Clear identification of bone structures is crucial for ultrasound-guided lumbar interventions, but it can be challenging due to the complex shapes of the self-shadowing vertebra anatomy and the extensive background speckle noise from th...
Publication · February 01, 2026
Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers
Publication · February 01, 2026
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