Research
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Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults
Abstract
Intrinsic functional connectivity of large-scale brain networks has been shown to change with aging and Alzheimer’s disease (AD). These alterations are thought to reflect changes in synaptic function, but the underlying biological mecha...
Publication · February 01, 2026
Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals
Publication · February 01, 2026
Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease
Abstract
Objective: Several models have been proposed for the evolution of Alzheimer’s disease (AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers during the preclinical phase of AD. Methods: We examined ...
Publication · February 01, 2026
VASCULAR RISK FACTORS AND CSF AD BIOMARKERS ARE INDEPENDENTLY ASSOCIATED WITH COGNITIVE DECLINE
Publication · February 01, 2026
The Occipital Emissary Vein: A Possible Marker for Pseudotumor Cerebri
Abstract
BACKGROUND AND PURPOSE: Transverse sinus stenosis can lead to pseudotumor cerebri syndrome by elevating the cerebral venous pressure. The occipital emissary vein is an inconstant emissary vein that connects the torcular herophili with t...
Publication · February 01, 2026
Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.
Abstract
Background Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. Purpose To investiga...
Publication · February 01, 2026
Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease
Abstract
The aim of this study is to identify the potential cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease and to evaluate these markers on independent CSF samples using parallel reaction monitoring (PRM) assays.
Publication · February 01, 2026
White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease
Abstract
Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of Alzheimer disease (AD). In a longitudinal study, we inve...
Publication · February 01, 2026
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