Research
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Identifying Changepoints in Biomarkers During the Preclinical Phase of AD
Abstract
Objective Several models have been proposed for the evolution of Alzheimer’s disease (AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers during the preclinical phase of AD. Methods We examined ni...
Publication · February 01, 2026
Phosphotyrosine profiling of human cerebrospinal fluid
Abstract
Cerebrospinal fluid (CSF) is an important source of potential biomarkers that affect the brain. Biomarkers for neurodegenerative disorders are needed to assist in diagnosis, monitoring disease progression and evaluating efficacy of ther...
Publication · February 01, 2026
Comparing Shunt Survival of Adult Hydrocephalus: An Analysis of Shunt Failure Using the National Longitudinal Database
Publication · February 01, 2026
ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes
Abstract
Objective To examine the long-term cognitive trajectories of individuals with normal cognition at baseline and distinct amyloid/tau/neurodegeneration (ATN) profiles. Methods Pooling data across 4 cohort studies, 814 cognitively normal p...
Publication · February 01, 2026
EFFECT OF PATIENT-SPECIFIC PRE-ANALYTIC VARIABLES ON CSF Aβ42 CONCENTRATIONS MEASURED ON AN AUTOMATED CHEMILUMINESCENT PLATFORM
Publication · February 01, 2026
SYSTEMIC INFLAMMATION, SELECTIVE DEGRADATION OF LARGE-SCALE FUNCTIONAL BRAIN NETWORKS, AND AMYLOID DEPOSITION
Publication · February 01, 2026
PLASMA MEASURES OF INFLAMMATION ASSOCIATED WITH CLINICAL PROGRESSION AND COGNITIVE DECLINE DURING PRECLINICAL AD
Publication · February 01, 2026
Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults
Abstract
Intrinsic functional connectivity of large-scale brain networks has been shown to change with aging and Alzheimer’s disease (AD). These alterations are thought to reflect changes in synaptic function, but the underlying biological mecha...
Publication · February 01, 2026
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