Research
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Biophysical Methods to Analyze Direct G-Protein Regulation of Neuronal Voltage-Gated Calcium Channels
Publication · February 17, 2026
De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy
Abstract
Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies that are characterized by seizures and developmental delay. DEEs are primarily attributed to genetic causes and an increasing number of cases have been...
Publication · February 17, 2026
Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases
Abstract
Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel NaV channel ligands. With the objective of discovering new blockers of NaV...
Publication · February 17, 2026
Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels
Abstract
Low-voltage-activated T-type Ca2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in determining firing activity pa...
Publication · February 17, 2026
Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia
Abstract
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic manner and are...
Publication · February 17, 2026
T‐type channels: A new route for calcium entry into platelets
Abstract
Blood platelets produced by bone marrow megakaryocytes play a fundamental role in the initiation of endogenous hemostasis and effective endothelial repair following vascular injury. Although most platelets are found circulating inactiva...
Publication · February 17, 2026
Cavβ surface charged residues contribute to the regulation of neuronal calcium channels
Abstract
Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They consist of a pore-forming subunit (Ca v α 1 ) that requires co-assembly with ancillary ...
Publication · February 17, 2026
Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels
Abstract
ABSTRACT Missense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson’s disease. We recently documented th...
Publication · February 17, 2026
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