Research
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The early ticking of the central circadian pacemaker: when and how (StarTicking)
StarTicking proposes to answer a long-standing question in the field: when and how the circadian clock starts ticking. With a multidisciplinary and integrated approach, we will understand mechanistically the development of the central circadian pa...
Project · February 17, 2026
How does exogenous alerting impact endogenous preparation on a temporal cueing task
Publication · February 17, 2026
T-type channels in neuropathic pain - Villain or victim?
Abstract
Neuropathic pain syndromes affect between 30 and 50% of the world population and represent a significant burden for patients, society, and healthcare systems. Many hypotheses have been formulated about the mechanisms of neuropathic pain...
Publication · February 17, 2026
Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice
Abstract
ABSTRACT In this brief report, we demonstrate that the Cav3.3 T-type voltage-gated calcium channel subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first showed that the Cacna1i gene encoding Cav3.3 ...
Publication · February 17, 2026
Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels
Publication · February 17, 2026
Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide
Abstract
Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique ...
Publication · February 17, 2026
Transcriptomic analysis of glycan-processing genes in the dorsal root ganglia of diabetic mice and functional characterization on Cav3.2 channels
Abstract
ABSTRACT Cav3.2 T-type calcium channels play an essential role in the transmission of peripheral nociception in the dorsal root ganglia (DRG) and alteration of Cav3.2 expression is associated with the development of peripheral painful d...
Publication · February 17, 2026
Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels
Abstract
Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel activity. Previous studies h...
Publication · February 17, 2026
A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H enco...
Publication · February 17, 2026
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