Research
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Etude de la dynamique de dégranulation des mastocytes et analyse de l'effet des éicosanoïdes dans la coopération entre mastocytes et lymphocytes T Helper
Abstract
Les mastocytes sont des cellules immunitaires présentes dans tous les tissus de l'organisme. Ils ont été depuis longtemps associés aux réponses allergiques, mais ces cellules sont aussi des acteurs majeurs de la réponse inflammatoire. L...
Publication · May 20, 2026
IL‐33 fine tunes mast cell degranulation and chemokine production at the single‐cell level
Publication · May 20, 2026
Direct monitoring of basophil degranulation by using avidin-based probes.
Publication · May 20, 2026
Local microvascular leakage promotes trafficking of activated neutrophils to remote organs
Abstract
Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact o...
Publication · May 20, 2026
T helper cell-licensed mast cells promote inflammatory Th17 cells
Abstract
CD4+ T helper cells (Th) infiltrate sites of inflammation and orchestrate the immune response by instructing local leukocytes. Mast cells (MCs) are tissue sentinel cells particularly abundant in skin and mucosa. Here, we analyzed the in...
Publication · May 20, 2026
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Abstract
Summary Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged mice, neutrophils adhered to vascular endothel...
Publication · May 20, 2026
Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma
Abstract
A protease–antiprotease imbalance is a feature of many chronic lung diseases, with concentrations and activity of several MMPs (matrix metalloproteinases) correlating with disease pathology. MMP-12 plays a prominent role in lung tissue ...
Publication · May 20, 2026
Investigation into the lung vasculature transcriptional signature during asthma using spatial transcriptomic
Publication · May 20, 2026
A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma
Abstract
Determining spatial location of cells within tissues gives vital insight into the interactions between resident and inflammatory cells and is a critical factor for uncoupling the mechanisms driving disease. Here, we apply single-cell sp...
Publication · May 20, 2026
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