Research
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Lower Rates of Preterm Birth in Women of Arab Ancestry: an Epidemiologic Paradox
Publication · May 20, 2026
Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma
Publication · May 20, 2026
Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma
Abstract
Allergic asthma generally starts during early life and is linked to substantial tissue remodelling and lung dysfunction. Although angiogenesis is a feature of the disrupted airway, the impact of allergic asthma on the pulmonary microcir...
Publication · May 20, 2026
Basophils: Regulators of lung inflammation over space and time
Abstract
Schuijs et al. highlight a novel role for basophils during allergic immune responses to house dust mites (HDM), revealing how interleukin-33 (IL-33)-activated basophils facilitate recruitment and extravasation of Th2 cells into the lungs.
Publication · May 20, 2026
Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A
Abstract
Neutrophil diapedesis is an immediate step following infections and injury and is driven by complex interactions between leukocytes and various components of the blood vessel wall. Here, we show that perivascular mast cells (MC) are key...
Publication · May 20, 2026
Vectorial Exposure and Fusion Of Secretory Granule Content At The Mast Cell Degranulatory Synapse
Publication · May 20, 2026
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence
Abstract
Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sus...
Publication · May 20, 2026
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