Research
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Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects
Abstract
Purpose Transcranial electrical current stimulation (tES or tCS, as it is sometimes referred to) has been proposed as non-invasive therapy for pharmacoresistant epilepsy. This technique, which includes direct current (tDCS) and alternat...
Publication · August 28, 2025
Signal processing and computational modeling for interpretation of SEEG-recorded interictal epileptiform discharges in epileptogenic and non-epileptogenic zones
Abstract
Objective. In partial epilepsies, interictal epileptiform discharges (IEDs) are paroxysmal events observed in epileptogenic zone (EZ) and non-epileptogenic zone (NEZ). IEDs’ generation and recurrence are subject to different hypotheses:...
Publication · August 28, 2025
Improving Fast Ripples Recording With Model-Guided Design of Microelectrodes
Abstract
Objective: Microelectrodes allow the recording of neural activities with a high spatial resolution. However, their small sizes result in high impedance causing high thermal noise and poor signal-to-noise ratio. In drug-resistant epileps...
Publication · August 28, 2025
Transition to seizure in focal epilepsy: From SEEG phenomenology to underlying mechanisms
Abstract
For the pre‐surgical evaluation of patients with drug‐resistant focal epilepsy, stereo‐electroencephalographic (SEEG) signals are routinely recorded to identify the epileptogenic zone network (EZN). This network consists of remote brain...
Publication · August 28, 2025
Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy
Publication · August 28, 2025
NeoCOMM: A Neocortical Neuroinspired Computational Model for the Reconstruction and Simulation of Epileptiform Events
Abstract
Understanding the pathophysiological dynamics which underline interictal epileptiform events (IEEs) such as epileptic spikes, spike-and-waves or High-frequency oscillations (HFOs) is of major importance in the context of neocortical ref...
Publication · August 28, 2025
Expansion of epileptogenic networks via neuroplasticity in neural mass models
Abstract
Neuroplasticity refers to functional and structural changes in brain regions in response to healthy and pathological activity. Activity dependent plasticity induced by epileptic activity can involve healthy brain regions into the epilep...
Publication · August 28, 2025
Localization of the epileptogenic network from scalp EEG using a patient-specific whole-brain model
Abstract
Abstract Computational modeling is a key tool for elucidating the neuronal mechanisms underlying epileptic activity. Despite considerable progress, existing models often lack realistic accuracy in representing electrophysiological epile...
Publication · August 28, 2025
eCOALIA: Neocortical neural mass model for simulating electroencephalographic signals
Publication · August 28, 2025
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