Research
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Feudalism, Collaboration and Path Dependence in England’s Political Development
Abstract: This article presents a formal model of path dependence inspired by England’s history. The introduction of feudalism after the Norman Conquest – the critical juncture – created a large elite that rebelled frequently. The king fought thes...
Publication · August 21, 2026
The Social Dynamics of Collective Action: Evidence from the Diffusion of the Swing Riots, 1830–1831
Abstract: Social unrest often begins suddenly and spreads quickly. What is the information that drives its diffusion? How is this information transmitted? And who responds to this information? We present a general framework that emphasizes three a...
Publication · August 21, 2026
Gentrification and Social Unrest: The Blitz, Urban Change and the 2011 London Riots
Abstract: Many of the world’s major cities have recently seen large episodes of social unrest. What is the relationship between the changes these cities have experienced, particularly in the form of gentrification, and urban riots? We address this...
Publication · August 21, 2026
Can Democratic Reforms Promote Political Activism? Evidence from the Great Reform Act of 1832
Abstract: Activists play a key role in the process of democratic transition and consolidation. How is their activism affected by democratic reforms? We study how local activism in England and Wales responded to the changes in representation introd...
Publication · August 21, 2026
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Publication · August 21, 2026
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Publication · August 21, 2026
SerpinB1 Promotes Pancreatic β-Cell Proliferation
Abstract
Summary Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β-cell proliferation have been elusive. We previously reported that the liver is a source ...
Publication · August 21, 2026
IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation
Abstract
There is great interest in therapeutically harnessing endogenous regenerative mechanisms to increase the number of β cells in people with diabetes. By performing whole‐genome expression profiling of zebrafish islets, we identified 11 se...
Publication · August 21, 2026
Investigating the association between prenatal exposure to folic acid and risk of neonatal diabetes/hyperglycemia and type 1 diabetes: A Norwegian register‐based study
Abstract
Experimental animal studies suggest a novel role for the folate receptor 1 in β‐cell differentiation in the pancreas, with potential implications for glycemic control. We tested the hypothesis of a protective association between prenata...
Publication · August 21, 2026
Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
Abstract
Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration. We found that both folate receptor 1 (folr1) overexpr...
Publication · August 21, 2026
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