Research
Find research shared by the Owlstown community.
Materializing the virtual? Post-digital intimacy and women players of otome video games in China
Publication · September 09, 2026
Roles in hematopoietic development
Using multiple loss- and gain-of-function murine models, we have established that Mll1 is essential for the development of HSCs in the aorta-gonad-mesonephros (AGM) region (PMID15030765). Using pluripotent cells, we have shown that MLL1 levels are...
Project · September 09, 2026
HMTs as drug targets
Chromosomal translocations within the MLL1 gene create fusion oncoproteins encoded by one of the two alleles. The remaining, wild-type MLL1 does not play a role in initiating or sustaining MLL-fusion oncoprotein initiated leukemia (PMID28609655 & ...
Project · September 09, 2026
Unique H3K4 HMT functions in vivo
Early on, our group employed conditional knockout approaches to discover that hematopoietic stem cells (HSCs) and pre-B cells are particularly sensitive to MLL1 levels for homeostasis (PMIDs 18371366, 29351999). We employed genomic and genetic met...
Project · September 09, 2026
KMT2A-rearranged leukemia: from mechanism to drug development
Abstract
Gene rearrangements of the human MLL gene (also known as KMT2A) generate multiple fusion oncoproteins which cause leukemia with poor prognosis. MLL is an epigenetic regulator that reads and writes epigenetic information and has an evolu...
Publication · September 09, 2026
Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia
Abstract
The clinical success of engineered, CD19-directed chimeric antigen receptor (CAR) T cells in relapsed, refractory B-cell acute lymphoblastic leukemia (B-ALL) has generated great enthusiasm for the use of CAR T cells in patients with cyt...
Publication · September 09, 2026
Miocene biostratigraphic framework and paleogeography of Barro Colorado Island, Isthmus of Panama
Publication · September 08, 2026
Geochemical evidence of drying during the 4.2 ka event in sediment cores from the Yucatán Peninsula, Mexico
Publication · September 08, 2026
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