Research
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Towards Leaner Rail Infrastructure: A Theoretical Framework Combining Value Stream Mapping and Last Planner
Publication · December 09, 2025
MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative movement and cognitive disorder characterized by abnormal accumulation of the microtubule-associated protein tau in the brain. Biochemically, inclusions in PSP are enriched for...
Publication · December 08, 2025
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Abstract
Nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 are cellular hallmarks of amyotrophic lateral sclerosis (ALS). TDP-43 nuclear loss causes de-repression of cryptic exons, yet cryptic alternative polyadenyl...
Publication · December 08, 2025
Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes
Abstract
Abstract In frontotemporal lobar degeneration (FTLD), pathological protein aggregation in specific brain regions is associated with declines in human-specialized social-emotional and language functions. In most patients, disease protein...
Publication · December 08, 2025
A study of RNA splicing and protein expression in the living human brain
Abstract
Due to the unavailability of living human brain tissue for molecular research, postmortem brain samples are currently the standard tissue source for molecular studies of the human brain. The Living Brain Project (LBP) was designed to te...
Publication · December 08, 2025
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Publication · December 08, 2025
Alzheimer’s disease transcriptional landscape in ex vivo human microglia
Publication · December 08, 2025
Traditional Judiya Leaders in Sudan as Actors of Humanitarian Diplomacy: Are They Eligible to Fulfill These Roles in the Darfur Humanitarian Crisis?
Abstract
This study explored Judiya which is the main mechanism for traditional mediation, reconciliation and justice in Darfur in Sudan, in relation to humanitarian diplomacy. Ajaweed (respected elders and traditional leaders) play a central ro...
Publication · December 08, 2025
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