Research
Find research shared by the Owlstown community.
Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid
Abstract
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making appropriate therapeutic decisi...
Publication · February 01, 2026
Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β‐amyloid protein (Aβ) in the extracellular matrix. The pathogenesis of ...
Publication · February 01, 2026
Development of a novel method for the quantification of tyrosine 39 phosphorylated alpha-synuclein in human cerebrospinal fluid
Abstract
Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making appropriate thera...
Publication · February 01, 2026
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases
Abstract
Alzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, there exist...
Publication · February 01, 2026
Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance
Abstract
Objective To determine whether MRI-based cerebrovascular reactivity (CVR) can predict cognitive performance independently of Alzheimer pathologic markers, we studied the relationship between cognition, CVR, and CSF-derived β-amyloid42 (...
Publication · February 01, 2026
Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease
Abstract
Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular diseas...
Publication · February 01, 2026
Reassessing accuracy of blood cell correction factor for traumatic lumbar puncture
Publication · February 01, 2026
Tau pathology mediates the effects of amyloid on neocortical tau propagation and neurodegeneration among individuals without dementia
Abstract
Amyloid is associated with greater tau pathology and is thought to facilitate tau propagation from the medial temporal lobe (MTL) to the neocortex, where tau is closely associated with local neurodegeneration. We used causal mediation a...
Publication · February 01, 2026
Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts
Abstract
Alzheimer's disease biomarkers are becoming increasingly important for characterizing the longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and for recruitment and treatment monitoring in clinical...
Publication · February 01, 2026
Sites
View all
Create your academic website in Owlstown
Start your academic website in just a few minutes. Keep it updated easily. No code, no server to maintain, so you can focus on your research.
Create your free website