Research
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A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension
Abstract
Ventricular collapse is a prevalent yet poorly understood complication of ventriculo-peritoneal shunting (VPS) in idiopathic intracranial hypertension (IIH). By identifying the risk factors of ventricular collapse (VC), this study aims ...
Publication · February 01, 2026
Association of midlife vascular risk and AD biomarkers with subsequent cognitive decline
Abstract
Objective To determine whether vascular risk and Alzheimer disease (AD) biomarkers have independent or synergistic effects on cognitive decline and whether vascular risk is associated with the accumulation of AD pathology as measured by...
Publication · February 01, 2026
Standardized regression-based clinical change score cutoffs for normal pressure hydrocephalus
Abstract
Background Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement form clinical sig...
Publication · February 01, 2026
Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder caused by neuronal loss that results in cognitive and functional impairment. Formation of neurofibrillary tangles composed of abnormal hyperphosphorylation of tau pr...
Publication · February 01, 2026
Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid
Abstract
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making appropriate therapeutic decisi...
Publication · February 01, 2026
Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β‐amyloid protein (Aβ) in the extracellular matrix. The pathogenesis of ...
Publication · February 01, 2026
Development of a novel method for the quantification of tyrosine 39 phosphorylated alpha-synuclein in human cerebrospinal fluid
Abstract
Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making appropriate thera...
Publication · February 01, 2026
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases
Abstract
Alzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, there exist...
Publication · February 01, 2026
Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance
Abstract
Objective To determine whether MRI-based cerebrovascular reactivity (CVR) can predict cognitive performance independently of Alzheimer pathologic markers, we studied the relationship between cognition, CVR, and CSF-derived β-amyloid42 (...
Publication · February 01, 2026
Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease
Abstract
Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular diseas...
Publication · February 01, 2026
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