Research
Find research shared by the Owlstown community.
Formal Learning and Implementation in Military Operations
Abstract: Militaries have increasingly invested in formal learning processes. However, recent research in security studies suggests that many lessons are collected but never implemented. In this study, we ask: why do militaries learn certain les...
Publication · August 22, 2025
PATH-13. APPLICATIONS OF SPATIAL TRANSCRIPTOMICS FOR THE DIAGNOSTICS OF GLIOMAS
Abstract
Due to their infiltrative growth, diffuse gliomas can pose a major challenge for neuropathologists. Lack of specific immunohistochemistry markers for some gliomas like IDH-wildtype glioblastoma can make it hard to identify the tumour c...
Publication · August 21, 2025
OS10.8.A APPLICATIONS OF NOVEL FFPE BASED TECHNOLOGIES FOR THE DIAGNOSTICS OF GLIOMAS
Abstract
Due to the lack of consistent tumour-cell specific markers, the diffuse brain invasion of glioblastoma (GB) presents a significant diagnostic challenge, especially for specimens with a low tumour cell fraction or scarce tissue. The onl...
Publication · August 21, 2025
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics
Abstract
The diagnostic landscape of brain tumors integrates comprehensive molecular markers alongside traditional histopathological evaluation. DNA methylation and next-generation sequencing (NGS) have become a cornerstone in central nervous sy...
Publication · August 21, 2025
P01.03.A DECIPHERING THE TUMOUR ECOSYSTEM IN GLIOMAS USING SPATIAL TRANSCRIPTOMICS
Abstract
Tumours are complex ecosystems comprised of tumour cells and various normal cell types. The interactions among these cells with diverse molecular characteristics lead to intratumoral heterogeneity and cancer evolution. However, little ...
Publication · August 21, 2025
Glycation, glycolysis, and neurodegenerative diseases: Is there any connection?
Publication · August 21, 2025
A recently isolated human commensal Escherichia coli ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage‐derived IncY plasmid
Abstract
The ubiquitous human commensal Escherichia coli has been well investigated through its model representative E. coli K‐12. In this work, we initially characterized E. coli Fec10, a recently isolated human commensal strain of phylogroup A...
Publication · August 21, 2025
High Rates of Genome Rearrangements and Pathogenicity of Shigella spp.
Abstract
Shigella are pathogens originating within the Escherichia lineage but frequently classified as a separate genus. Shigella genomes contain numerous insertion sequences (ISs) that lead to pseudogenisation of affected genes and an increase...
Publication · August 21, 2025
PATH-46. COMPUTATIONAL HISTOPATHOLOGY INFORMED RAPID TARGETED NANOPORE SEQUENCING ENABLES AFFORDABLE NEXT DAY REPORTING OF COMPREHENSIVE MOLECULAR MARKERS FOR CNS TUMOUR DIAGNOSTICS
Abstract
Integrative brain tumour diagnostics indisputably requires comprehensive reporting of molecular markers. The 2021 WHO classification of central nervous system (CNS) tumours substantially increased the set of markers for routine evaluat...
Publication · August 21, 2025