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Single-Center Study of Therapeutic Apheresis in 24 Male Patients from the MENA Region: Reduction of Lipids, Inflammatory Markers, Autoantibodies, and Implications for Fatigue, Genetics, and Aging
Abstract
Abstract Cardiovascular and metabolic disorders, particularly diabetes and obesity, are highly prevalent in the Middle East and North Africa (MENA) region, exhibiting some of the highest global incidence rates. These conditions signific...
Publication · August 10, 2026
Stem Cells within the HPA Axis in Tissue Homeostasis and Disease.
Abstract
The hypothalamus-pituitary-adrenal (HPA) axis is crucial for the energy metabolism, cardiovascular function, and stress response. Importantly, neuronal signalling circuits in the hypothalamus, along with hormones released from the pitui...
Publication · August 10, 2026
A Physics-Informed Reduced-Order Lumped Aging Framework for Lithium-Ion Batteries Under Real-World EV Driving Cycles
Abstract
Lithium-ion batteries (LIBs) dominate the electric vehicle (EV) market, but highly transient operations, like extreme fast charging and regenerative braking, accelerate coupled degradation mechanisms. The most critical of these, solid-ele...
Publication · August 10, 2026
Therapeutic apheresis: A promising method to remove microplastics?
Abstract
Microplastics and nanoplastics have emerged as a major and growing health concern, with recent data revealing alarming levels of human exposure and contamination. Thus, there is a clear and urgent need for an effective method to remove ...
Publication · August 10, 2026
Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells
Abstract
Phaeochromocytomas (PCCs) and paragangliomas (PGLs), are rare neuroendocrine tumours that arise in the neural crest (NC)-derived adrenal medulla and the paraganglia, respectively. Approximately 10%-15% of patients with PCCs and 35%-40% ...
Publication · August 10, 2026
Adrenal Cortical Steroidogenic Enzyme Expression is Associated with Hypertension, Obesity and Corticosteroid Use: A Tissue Microarray Study of Human Adrenal Tissue
Abstract
Abstract Steroidogenesis in the human adrenal cortex follows a distinct anatomical and functional zonation, which is essential for maintaining electrolyte balance, stress response, and metabolic homeostasis. Dysregulation of this tightl...
Publication · August 10, 2026
Sexual Dimorphism in the Adrenal Cortex: Implications for Stress Responsiveness.
Abstract
The stress response is regulated by the hypothalamic-pituitary-adrenal (HPA) axis, which is activated in response to both physical and psychological stressors. Prolonged activation of this axis contributes to sex-specific patterns of st...
Publication · August 10, 2026
Therapeutic apheresis: An effective strategy for a combined targeting of circulating lipoproteins, inflammatory markers, PFAS, and microplastics in cardiometabolic and neurodegenerative disease?
Abstract
Lipoprotein apheresis is a highly effective and well-established extracorporeal therapy designed to remove lipoproteins from human circulation on a large scale, particularly in patients with progressive cardiovascular diseases when con...
Publication · August 10, 2026
The human microplastic burden and brain health: From measurement to pathophysiology and removal
Abstract
Microplastics and nanoplastics now contaminate every human compartment examined, including blood, placenta, atheromatous plaque, and brain tissue. The brain warrants particular attention. Decedent brain tissue has been shown to carry mi...
Publication · August 10, 2026
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