Research
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SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain Disorders
Abstract
Most genetic risk variants for neurological diseases are located in non-coding regulatory regions, where they may often act as expression quantitative trait loci (eQTLs), modulating gene expression and influencing disease susceptibility...
Publication · October 29, 2025
Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells
Abstract
Myeloid cells undergo large changes to their gene expression profile in response to inflammatory stimulation. This includes an increase in post-transcriptional modifications carried out by adenosine-to-inosine (A-to-I) and cytosine-to-u...
Publication · October 29, 2025
The human microglia responsome: a resource for microglia states in health and disease.
Publication · October 29, 2025
Regulatory landscape of Alzheimer's disease variants in human microglia
Publication · October 29, 2025
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing.
Publication · October 29, 2025
Alzheimer's disease transcriptional landscape in ex vivo human microglia.
Publication · October 29, 2025
Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease
Publication · October 29, 2025
Genetics of the human microglia regulome refines Alzheimer’s disease risk loci
Publication · October 29, 2025
Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
Abstract
Genome-wide association studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson’s Disease (PD) but identifying putative causal genes and the underlying mechanisms remains challenging. Here, we leverage large...
Publication · October 29, 2025
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
Abstract
Cytoplasmic mislocalization of FUS-ALS mutants determines aberrant FMRP condensates and protein synthesis repression. FUsed in Sarcoma (FUS) is a multifunctional RNA binding protein (RBP). FUS mutations lead to its cytoplasmic mislocali...
Publication · October 29, 2025
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