Research
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Optimized Patient-Specific Catheter Placement for Convection-Enhanced Nanoparticle Delivery in Recurrent Glioblastoma
Publication · November 08, 2025
Mathematical modelling of the dynamics of image-informed tumor habitats in a murine model of glioma
Abstract
Tumors exhibit high molecular, phenotypic, and physiological heterogeneity. In this effort, we employ quantitative magnetic resonance imaging (MRI) data to capture this heterogeneity through imaging-based subregions or “habitats” in a m...
Publication · November 08, 2025
PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects
Abstract
In silico models of biological systems are usually very complex and rely on a large number of parameters describing physical and biological properties that require validation. As such, parameter space exploration is an essential compone...
Publication · November 08, 2025
The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI–Dynamic Contrast‐Enhanced challenge
Abstract
Ktrans$$ {K}^{\mathrm{trans}} $$ has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for Ktrans$$ {K}^{\mathrm{trans...
Publication · November 08, 2025
Patient-specific, mechanistic models of tumor growth incorporating artificial intelligence and big data
Abstract
Despite the remarkable advances in cancer diagnosis, treatment, and management that have occurred over the past decade, malignant tumors remain a major public health problem. Further progress in combating cancer may be enabled by person...
Publication · November 08, 2025
Comparing mechanism-based and machine learning models for predicting the effects of glucose accessibility on tumor cell proliferation
Abstract
Glucose plays a central role in tumor metabolism and development and is a target for novel therapeutics. To characterize the response of cancer cells to blockade of glucose uptake, we collected time-resolved microscopy data to track the...
Publication · November 08, 2025
PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects
Abstract
In silico models of biological systems are usually very complex and rely on several parameters describing physical and biological properties that require validation. As such, parameter space exploration is an essential component of comp...
Publication · November 08, 2025
Fast model calibration for predicting the response of breast cancer to chemotherapy using proper orthogonal decomposition
Publication · November 08, 2025
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