Vilgelm Laboratory
Translational Oncology Research
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The gastrin gene promoter is regulated by p73 isoforms in tumor cells
Publication
Abstract p73, a new p53 family member, is a transcription factor that is increasingly recognized in cancer research as an important pla...
RNA interference: Biology and prospects of application in biomedicine and biotechnology
Publication
Abstract RNA interference is one of the most important mechanisms regulating gene expression. Small interfering RNAs (siRNAs) play an e...
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Publication
Abstract PTEN is a tumor suppressor gene frequently mutated in human cancers. In vitro and in vivo studies have shown that PTEN can exe...