Research
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BREADR: An R Package for the Bayesian Estimation of Genetic Relatedness from Low-coverage Genotype Data
Publication · June 12, 2025
Mode of delivery in the second stage of labour and subsequent preterm birth
Preterm birth occurs in approximately 8% of deliveries in Canada and is a leading cause of infant death and morbidity throughout the life course. While sPTB is associated with several different risk factors including prior sPTB, socioeconomic stat...
Project · June 11, 2025
Trends in second-stage cesarean delivery in Canada and associated maternal and perinatal morbidity
Deliveries can occur either before labour, during the first stage of labour (prior to full cervical dilation), or during the second stage of labour (after full cervical dilation. In Canada, the distribution of deliveries between vaginal and cesare...
Project · June 11, 2025
Temporal trends in second-stage cesarean birth in Ontario, Canada, 2012–2021
Publication · June 11, 2025
8602 Classical progesterone signaling in kisspeptin neurons is not required for negative feedback regulation of the GnRH pulse generator in mice
Abstract
Abstract Disclosure: K.M. Dillon: None. D.B. Lohr: None. A.G. Novak: None. A.V. Petriv: None. N.T. Neifert: None. A.M. Moore: None. Mammalian reproductive function depends on the ability of progesterone to suppress pulsatile gonadotropi...
Publication · June 11, 2025
7869 Conditional deletion of androgen receptors from kisspeptin neurons only partially rescues the reproductive phenotype of a prenatal androgen-induced mouse model of polycystic ovary syndrome
Abstract
Abstract Disclosure: A.G. Novak: None. A.V. Petriv: None. D.B. Lohr: None. K.M. Dillon: None. N.T. Neifert: None. A.M. Moore: None. Polycystic ovary syndrome (PCOS) is a prevalent cause of infertility in people with ovaries of reproduct...
Publication · June 11, 2025
Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome.
Abstract
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate t...
Publication · June 11, 2025
The deletion of nuclear progesterone receptors from kisspeptin cells does not impair negative feedback in female mice.
Abstract
Reproductive function in mammals depends on the ability of progesterone to suppress pulsatile gonadotrophin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in a homeostatic negative feedback loop. Previous research ident...
Publication · June 11, 2025
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