Research
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A 22-gene transcriptomic model indicating individual therapy durations in multidrug-resistant tuberculosis
Abstract
Emerging multidrug-resistant tuberculosis is a major global health challenge. The World Health Organization currently recommends treatment durations of 9-18 months or more for patients with multidrug-resistant tuberculosis. We identifie...
Publication · September 01, 2025
Appropriateness of diagnosis and antibiotic use in sepsis patients admitted to a tertiary hospital in Indonesia
Abstract
ABSTRACT Objective To evaluate the diagnostic and antibiotic treatment strategies for patients suspected of sepsis, in a tertiary hospital in Indonesia. This can identify areas for improvement in care provided, and inform diagnostic and...
Publication · September 01, 2025
Laboratory-based versus population-based surveillance of antimicrobial resistance to inform empirical treatment for suspected urinary tract infection in Indonesia
Abstract
Surveillance of antimicrobial resistance (AMR) enables monitoring of trends in AMR prevalence. WHO recommends laboratory-based surveillance to obtain actionable AMR data at local or national level. However, laboratory-based surveillance...
Publication · September 01, 2025
Clinical Reasoning Underlying Guideline Nonadherence in Urinary Tract Infections in Nursing Homes.
Publication · September 01, 2025
Monocyte-to-lymphocyte ratio as a predictor of TB among people living with HIV.
Abstract
BACKGROUND: Diagnostic tools to identify incipient or subclinical TB stages will be helpful for preventive intervention. A simple biomarker to predict TB may be the monocytes to lymphocytes ratio (ML ratio) in peripheral blood.METHODS: ...
Publication · September 01, 2025
Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
Abstract
Background The World Health Organization recommends standardised treatment durations for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a biomarker for individualised therapy durations for patients ...
Publication · September 01, 2025
Defining Outcomes of Tuberculosis (Treatment): From the Past to the Future
Abstract
Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB reduces mortality dramatically and should maximize cure, preventing ongoing transmission and TB sequelae. However, predicting the risk of failure an...
Publication · September 01, 2025
Use and impact of molecular methods for detecting drug-resistant TB.
Publication · September 01, 2025
Antimicrobial resistance among uropathogens in the Asia-Pacific region: a systematic review
Abstract
Abstract Background Antimicrobial resistance (AMR) in urinary tract infections (UTI) is a global public health problem. However, estimates of the prevalence of AMR, required for empirical treatment guidelines, are lacking for many regio...
Publication · September 01, 2025
Incidence and factors associated with active tuberculosis among people living with HIV after long-term antiretroviral therapy in Thailand: a competing risk model
Abstract
Background Antiretroviral therapy (ART) is known to reduce tuberculosis (TB) incidence among people living with HIV (PLWH). However, studies describing the impact of long-term ART and CD4 count recovery on TB incidence remain scarce due...
Publication · September 01, 2025
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