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Reduced neural encoding of utility prediction errors in cocaine addiction
Abstract
Summary Influential accounts of addiction posit alterations in adaptive behavior driven by deficient dopaminergic prediction errors (PE) signaling the discrepancy between actual and expected reward. Dopamine neurons encode these error s...
Publication · June 26, 2026
Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.
Abstract
Movies captivate groups of individuals (the audience), especially if they contain themes of common motivational interest to the group. In drug addiction, a key mechanism is maladaptive motivational salience attribution whereby drug cues...
Publication · June 26, 2026
Pump the brakes: identifying neurobiological targets to enhance inhibitory control in drug addiction
Publication · June 26, 2026
Prefrontal cortex activity increases after inpatient treatment for heroin addiction
Publication · June 26, 2026
Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder
Abstract
Key Points Question Does white matter microstructure change during medication-assisted treatment in individuals with heroin use disorder (HUD)? Findings In this cohort study of 34 inpatient individuals with HUD and 25 healthy controls, ...
Publication · June 26, 2026
The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions
Abstract
Originally postulated in 2001, the impaired response inhibition and salience attribution (iRISA) model of addiction highlights the prefrontal cortex (especially the orbitofrontal, dorsolateral, anterior cingulate, and inferior frontal r...
Publication · June 26, 2026
The neural signature of methylphenidate-enhanced memory disruption in human drug addiction: a randomized clinical trial
Abstract
Background: Drug-related memories can hinder abstinence goals in drug addiction. Promoting non-drug memories via ventromedial prefrontal cortex- (vmPFC) and amygdala-guided extinction yields mixed success. Post-retrieval extinction (RE)...
Publication · June 26, 2026
Peripheral Blood Cytokines as Markers of Longitudinal Change in White Matter Microstructure Following Inpatient Treatment for Opioid Use Disorders
Abstract
Background Opioid use disorder (OUD) causes major public health morbidity and mortality. Although standard-of-care treatment with medications for OUD (MOUDs) is available, there are few biological markers of the clinical process of reco...
Publication · June 26, 2026
The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction
Abstract
Significance In people with drug addiction, we report that the pharmacological enhancement of memory modulation normalized impairments in prefrontal cortex function in response to drug-associated cues, with effects associated with lab-b...
Publication · June 26, 2026
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