Research
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Before and after: lumbar puncture complicated by cerebral venous sinus thrombosis
Publication · February 01, 2026
Assessing the predictive value of common gait measure for predicting falls in patients presenting with suspected normal pressure hydrocephalus
Abstract
Objective To assess the predictive value of common measures validated to predict falls in other geriatric populations in patients presenting with suspected Normal Pressure Hydrocephalus (NPH). Methods One hundred ninety-five patients ov...
Publication · February 01, 2026
Cerebrospinal fluid lipidomics for biomarkers of Alzheimer's disease.
Abstract
Alzheimer's disease (AD) is the most common cause of dementia and is associated with serious neurologic sequelae resulting from neurodegenerative changes. Identification of markers of early-stage AD could be important for designing stra...
Publication · February 01, 2026
CSF SNAP‐25 dynamics in healthy aging and across the spectrum of Alzheimer's disease
Abstract
The turnover of synaptic proteins with aging and in different phases of AD is poorly understood. We measured CSF SNAP‐25, a protein localized to the presynaptic processes, using a novel SIMOA assay across 2 cohorts comparing cognitively...
Publication · February 01, 2026
Systematic volumetric analysis predicts response to CSF drainage and outcome to shunt surgery in idiopathic normal pressure hydrocephalus
Abstract
Idiopathic normal pressure hydrocephalus (INPH) is a neurodegenerative disorder characterized by excess cerebrospinal fluid (CSF) in the ventricles, which can be diagnosed by invasive CSF drainage test and treated by shunt placement. He...
Publication · February 01, 2026
MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols
Abstract
The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple ...
Publication · February 01, 2026
Cognitive and gait outcomes after primary endoscopic third ventriculostomy in adults with chronic obstructive hydrocephalus.
Abstract
OBJECTIVE
The object of this study was to determine the short- and long-term efficacy of primary endoscopic third ventriculostomy (ETV) on cognition and gait in adults with chronic obstructive hydrocephalus.
METHODS
Patients were prosp...
Publication · February 01, 2026
Intracranial Hypotension Related Skull Remodeling with Enophthalmos
Abstract
Drs Pirakitikulr and Tse describe their experience managing a patient with progressive enophthalmos following cerebrospinal fluid (CSF) shunting. The case is interesting and nicely illustrates several valuable features of this uncommon ...
Publication · February 01, 2026
Longitudinal CSF biomarker trajectories from middle age to late adulthood
Abstract
Current cerebrospinal fluid (CSF) biomarker data of preclinical AD are based largely on cross‐sectional studies across the disease spectrum and short‐term longitudinal studies, with most studies conducted among older adults. However, ne...
Publication · February 01, 2026
Health Conditions Associated with Alzheimer's Disease and Vascular Dementia
Abstract
We examined medical records to determine health conditions associated with dementia at varied intervals prior to dementia diagnosis in participants from the Baltimore Longitudinal Study of Aging (BLSA).
Publication · February 01, 2026
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