Research
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Economic costs of perinatal depression and anxiety in a lower middle income country: Pakistan.
Publication · February 18, 2026
Optimizing psychotherapies for perinatal depressive symptom dimensions by strengthening social support networks: an exploratory mediation analysis approach
Abstract
Abstract The Thinking Healthy Program (THP) is a multicomponent low-intensity cognitive behavioral therapy-based psychosocial intervention. This intervention has been shown to be clinically effective in perinatal depression (PND) and fe...
Publication · February 18, 2026
Effectiveness of YCMAP (youth culturally adapted manual assisted problem solving) intervention in adolescents after self-harm in Pakistan: multicentre, randomised controlled trial
Abstract
Abstract Objective To evaluate the clinical effectiveness of the YCMAP intervention (Youth Culturally Adapted Manual Assisted Problem Solving) for adolescents after self-harm in Pakistan. Design Multicentre, randomised controlled trial ...
Publication · February 18, 2026
Cost-effectiveness of a technology-assisted peer-delivered perinatal mental health intervention in Pakistan: an economic evaluation using trial evidence
Abstract
Introduction Perinatal depression in low- and middle-income countries is a global health concern. Interventions to support women suffering from perinatal depression using mental health specialists, such as the WHO Thinking Healthy Progr...
Publication · February 18, 2026
Efficacy of a Culturally Adapted, Cognitive Behavioral Therapy-Based Intervention for Postnatal Depression in British South Asian Women (ROSHNI-2): A Multicentre, Randomized Controlled Trial
Abstract
(Abstracted from Lancet 2024;404:1430–1443)
About 1 in 8 women experience postnatal depression. In the United Kingdom, common perinatal mental disorders, including postnatal depression, are estimated to cost about £8.1 billion for each...
Publication · February 18, 2026
Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial
Abstract
Background In Pakistan, the mental health care for persons living with disabilities is insufficient, lacking a holistic approach to address their needs. This research evaluates the adapted PM+’s (IA-PM+) initial efficacy and acceptabili...
Publication · February 18, 2026
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial
Abstract
Perinatal depression affects one in four women in low- and middle-income countries. The World Health Organization’s Thinking Healthy Programme (WHO-THP) is an established ‘task-shared’ cognitive-behavioral therapy intervention for perin...
Publication · February 18, 2026
Efficacy of a Culturally Adapted, Cognitive Behavioural Therapy-based Intervention for Postnatal Depression in British South Asian Women (ROSHNI-2): A Multicentre, Randomised Controlled Trial
Abstract
(Lancet. 2024;404:1430–43. DOI: 10.1016/S0140-6736(24)01612-X)
Postnatal depression (PPD) is a significant concern that requires timely and effective interventions to prevent negative outcomes for both mothers and their children in the...
Publication · February 18, 2026
Comparing standard and technology-assisted peer-delivered CBT for perinatal depression: A causal mediation study
Abstract
Abstract The ENHANCE non-inferiority trial that took place in a deprived setting in Pakistan demonstrated that a technology-assisted digital adaptation of the Technology Assisted Thinking Healthy Programme (THP-TAP) was no different tha...
Publication · February 18, 2026
Innovating perinatal mental health delivery in Pakistan: a public-private partnership model in primary care.
Abstract
In low- and middle-income countries (LMICs), mental health systems face persistent challenges in access, coverage, and quality, especially for vulnerable groups such as perinatal women. This case study from Pakistan describes an innovat...
Publication · February 18, 2026
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