Research
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Sex-dependent regulation of cardiac metabolism and its impact on post-infarction remodeling.
While younger and age-matched females consistently demonstrate greater intrinsic cardiac resilience following ischemic injuries compared to males, the underlying systemic and metabolic mechanisms driving these differences remain poorly understood....
Project · May 20, 2026
Pathophysiological and etiological mechanisms of peripartum cardiomyopathy.
Peripartum cardiomyopathy (PPCM) is a life-threatening, idiopathic systolic dysfunction that manifests late in pregnancy or up to one year postpartum. While clinical risk factors like advanced maternal age, lactation, pre-eclampsia, and increased ...
Project · May 20, 2026
Understanding the Mechanisms Contributing to Pregnancy-Induced Cardiac Growth and its Reversal
While our current research has successfully established a quantitative atlas of the structural and metabolic adaptations that define a healthy pregnancy and postpartum period , vital questions remain regarding how these regulatory mechanisms are i...
Project · May 20, 2026
Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism.
Abstract
The endoplasmic reticulum/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1), a key mediator of store-operated Ca2+ entry, is expressed in cardiomyocytes and has been implicated in regulating multiple cardiac proc...
Publication · May 20, 2026
Cardiomyocyte ZKSCAN3 regulates remodeling following pressure‐overload
Abstract
Autophagy is important for protein and organelle quality control. Growing evidence demonstrates that autophagy is tightly controlled by transcriptional mechanisms, including repression by zinc finger containing KRAB and SCAN domains 3 (...
Publication · May 20, 2026
Cardiac mitochondrial metabolism during pregnancy and the postpartum period
Publication · May 20, 2026
Abstract P2019: Do Changes In Metabolism Or Lactation Mediate The Reversal Of Pregnancy-induced Cardiac Growth?
Abstract
During pregnancy, the maternal heart undergoes physiologic growth, which reverses following parturition and is associated with the restoration of hemodynamic parameters. However, the molecular processes underlying the reversal of pregn...
Publication · May 20, 2026
Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth.
Publication · May 20, 2026
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