Research
Find research shared by the Owlstown community.
Evolutionary genomics in pumpkins
The evolutionary history of pumpkins (Cucurbita) is peculiar, as they have experienced a whole-genome duplication (WGD) event around 30 Mya. This WGD event allowed pumpkins to evolve novel genomic elements, which likely increased the evolutionary ...
Project · November 02, 2025
Integrating Performing Arts into the Undergraduate Curriculum: A Production of Dostoevsky’s “White Nights”
My experience of producing a student-led adaptation of Fyodor Dostoevsky's "White Nights" as part of an Undergraduate Course for Additional English at Mount Carmel College, Bangalore
Project · November 02, 2025
Copackaging of multiple adeno-associated viral vectors in a single production step.
Publication · November 02, 2025
B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study
Abstract
Gene therapy strategies for congenital myopathies may require repeat administration of adeno-associated viral (AAV) vectors due to aspects of the clinical application, such as: (i) administration of doses below therapeutic efficacy in p...
Publication · November 02, 2025
Immune Responses and Hypercoagulation in ERT for Pompe Disease Are Mutation and rhGAA Dose Dependent
Abstract
Enzyme replacement therapy (ERT) with recombinant human acid-α-glucosidase (rhGAA) is the only FDA approved therapy for Pompe disease. Without ERT, severely affected individuals (early onset) succumb to the disease within 2 years of lif...
Publication · November 02, 2025
BAFF blockade prevents anti-drug antibody formation in a mouse model of Pompe disease.
Publication · November 02, 2025
Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease.
Publication · November 02, 2025
Targeted approaches to induce immune tolerance for Pompe disease therapy
Abstract
Enzyme and gene replacement strategies have developed into viable therapeutic approaches for the treatment of Pompe disease (acid α-glucosidase (GAA) deficiency). Unfortunately, the introduction of GAA and viral vectors encoding the enz...
Publication · November 02, 2025
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