Research
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Calculating and Reporting Coefficients of Variation for DIA-Based Proteomics
Publication · March 24, 2026
Multibatch TMT Reveals False Positives, Batch Effects and Missing Values*
Abstract
Analysis of 24 TMT 10-plex batches revealed an inflation in missing values and reduced inter-batch accuracy as multiple TMT batches are integrated. Our data also highlights the incidence of false positives exemplified by Y chromosome pe...
Publication · March 24, 2026
Erosion of human X chromosome inactivation alters proteome expression from genes across the X chromosome and all autosomes
Abstract
We thank all of our collaborators who worked on the HipSci project. We would also like to thank D. Cantrell, M. Stavridis, G. Findlay, J. Marchingo and F. Dossin for all the insightful discussions as well as L. Davidson within the Unive...
Publication · March 24, 2026
Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
Abstract
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and ...
Publication · March 24, 2026
Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection
Abstract
Graphical abstract Summary of the study. Peripheral blood neutrophils from >200 hospitalised patients across three patient groups (coronavirus disease 2019 (COVID-19), non-COVID-19 lower respiratory tract infection (LRTI) and matched co...
Publication · March 24, 2026
Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples
Abstract
Data-independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant. Using ...
Publication · March 24, 2026
Rhetorical Figures, Grammatical Constructions, and Form/Meaning Alliances in Pretrained Language Models
Publication · March 24, 2026
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