Blog Posts
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Six things go wrong for cancer to grow
Cancer isn't a single disease but rather a multitude of conditions that arise at varying ages, grow at different rates, and manifest in numerous ways. However, the cells that constitute these tumors share plenty of features and employ similar stra...
Post · January 09, 2023
A cell eating itself, leveraging autophagy to treat cancer
What is autophagy?
Autophagy is a process by which the cell can maintain and recycle its components. The process starts by forming a membrane around the target. This structure then is fused with lysosomes which contain enzymes to lyse and degrad...
Post · January 09, 2023
Cancer evolution by non-Darwinian mechanisms
In the Darwinian model of cancer evolution, the variations among cancer cells result in differential survival of some clones, which dominate the tumor mass. This view was challenged by discovering that tumors comprised multiple subclones that diff...
Post · January 09, 2023
The evolution of self-consumption
To study the evolution of a body part or a trait, one needs to address two questions. First, what is the trait for? Second, how could it evolve in small steps that gave some advantage to the organism that carried them? It is also necessary to sugg...
Post · January 09, 2023
The non-genetic determinants in cancer evolution
When one lines up the genomes of related species, they vary in more than the protein-coding sequences. In fact, most differences fall outside these regions, given the small fraction they represent. Genomes differ with respect to sequences that reg...
Post · January 09, 2023
Gene expression adaptation in yeast, mice, and humans
Coding vs. non-coding variants
Mutations produce novelty. The kind of novel variants on which selection acts. These variants fall within two broad categories depending on location in the genome: protein-coding and regulatory sequences. The forme...
Post · January 09, 2023
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